Protein K48-linked deubiquitination

Across TCGA cell cohorts, RNA activity of the Protein K48-linked deubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLIC4, CAPN8, and TUBB, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CLIC4 grouped by Protein K48-linked deubiquitination-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CLIC4 →	-0.985	-0.334	.007	<.001	3	4
LUNG_NSCLC_LUAD	CAPN8 →	+1.966	+1.031	.006	<.001	2	5
LUNG_NSCLC_LUAD	TUBB →	-0.607	-0.943	.005	<.001	3	4
LUNG_SCLC	RBPMS2 →	-1.974	-0.874	.001	.002	3	3
LUNG_SCLC	RASSF5 →	+1.650	+0.939	.001	.009	3	3
OVARY	FBXO8 →	+0.754	+0.724	.007	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CLIC4 by Protein K48-linked deubiquitination activity — SOFT_TISSUE

Explore this box plot interactively →