Protein K48-linked deubiquitination

Across TCGA cell cohorts, RNA activity of the Protein K48-linked deubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OTUD3, ZNF451, and RBM12B, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein K48-linked deubiquitination activity versus OTUD3 in SOFT_TISSUE (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OTUD3 →	+1.153	+0.074	<.001	<.001	3	16
BLOOD_Lymphoma	ZNF451 →	+0.792	+0.055	.004	.002	3	14
SOFT_TISSUE	RBM12B →	+1.015	+0.088	<.001	<.001	3	13
LUNG_NSCLC_LUSC	VCPIP1 →	+1.067	+0.095	.001	.001	3	13
LUNG_NSCLC_LUSC	RNF169 →	+1.004	+0.090	<.001	<.001	3	12
SOFT_TISSUE	ZBTB34 →	+0.708	+0.069	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071108 vs OTUD3 — SOFT_TISSUE

Explore this scatter interactively →