Protein K48-linked deubiquitination

Across TCGA cell cohorts, RNA activity of the Protein K48-linked deubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TWNK, UBE2O, and PHF14, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein K48-linked deubiquitination activity versus TWNK in BLOOD_Myeloma (Pearson r = 0.84).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	TWNK →	+1.089	+0.512	.002	<.001	3	5
PANCREAS	UBE2O →	+0.521	+0.973	.008	.003	3	5
LIVER	PHF14 →	+1.022	+0.219	.002	.008	3	4
KIDNEY	GLA →	-1.055	-0.368	.006	.007	3	4
KIDNEY	ZC3H7A →	+0.612	+0.368	<.001	<.001	3	4
BLOOD_Lymphoma	EEF1B2 →	+0.759	+0.214	.003	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071108 vs TWNK — BLOOD_Myeloma

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