Response to interleukin-9

Across TCGA cell cohorts, RNA activity of the Response to interleukin-9 pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are YPEL2, IRF5, and MLYCD, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, YPEL2 grouped by Response to interleukin-9-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	YPEL2 →	+2.690	+1.522	.002	.003	3	4
OESOPHAGUS	IRF5 →	+1.444	+1.365	<.001	<.001	3	4
LUNG_SCLC	MLYCD →	-0.770	-1.279	.006	.006	3	3
BREAST	NFIL3 →	+0.972	+0.986	.003	.003	2	4
BREAST	ATG16L2 →	-1.447	-0.877	<.001	.008	3	3
BREAST	CRADD →	-0.909	-1.098	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

YPEL2 by Response to interleukin-9 activity — SOFT_TISSUE

Explore this box plot interactively →