Response to interleukin-9

Across TCGA cell cohorts, RNA activity of the Response to interleukin-9 pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STAT1, PPP1R3B, and CAP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to interleukin-9 activity versus STAT1 in BLOOD_Myeloma (Pearson r = 0.91).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	STAT1 →	+4.240	+2.406	.001	<.001	3	7
BLOOD_Lymphoma	PPP1R3B →	+2.067	+1.403	.001	.002	3	6
BLOOD_Lymphoma	CAP1 →	+0.878	+1.290	<.001	.001	2	6
BLOOD_Lymphoma	IFI35 →	+2.696	+1.362	<.001	<.001	3	5
BLOOD_Lymphoma	WDFY1 →	+1.284	+1.325	.004	.001	3	4
CNS	FTL →	+2.058	+1.194	.005	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071104 vs STAT1 — BLOOD_Myeloma

Explore this scatter interactively →