DNA conformation change

Across TCGA cell cohorts, RNA activity of the DNA conformation change pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TIAL1, TOP2A, and SLC1A4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TIAL1 grouped by DNA conformation change-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TIAL1 →	-0.572	-0.250	.005	.003	3	5
OESOPHAGUS	TOP2A →	-1.128	-0.228	.007	<.001	3	5
URINARY_TRACT	SLC1A4 →	+1.622	+0.240	.001	.002	3	4
OESOPHAGUS	TPRKB →	-0.695	-0.227	.005	.001	2	5
LARGE_INTESTINE	CUL4B →	-0.778	-0.328	.002	.005	3	4
LUNG_SCLC	LRRC8B →	+1.023	+0.371	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TIAL1 by DNA conformation change activity — BLOOD_Leukemia

Explore this box plot interactively →