DNA conformation change

Across TCGA cell cohorts, RNA activity of the DNA conformation change pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NASP, TOP2B, and SMARCC1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA conformation change activity versus NASP in BLOOD_Leukemia (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NASP →	+0.727	+0.218	<.001	.003	3	8
URINARY_TRACT	TOP2B →	+1.090	+0.507	.001	<.001	3	8
LUNG_NSCLC_LUAD	SMARCC1 →	+0.670	+0.213	<.001	<.001	3	7
LUNG_NSCLC_LUAD	DBR1 →	+0.442	+0.190	<.001	<.001	3	6
LUNG_NSCLC_LUAD	SUPT16H →	+0.504	+0.172	<.001	<.001	3	6
BLOOD_Leukemia	TRA2B →	+0.648	+0.203	<.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071103 vs NASP — BLOOD_Leukemia

Explore this scatter interactively →