Regulation of phospholipid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Regulation of phospholipid biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VIM_S22, SEPTIN4_S432, and SSC5D, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of phospholipid biosynthetic process activity versus VIM_S22 in OV (Pearson r = 0.00).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	VIM_S22 →	+0.769	+0.053	.006	.003	3	8
CCRCC	SEPTIN4_S432 →	+0.451	+0.058	<.001	<.001	3	8
BRCA	SSC5D →	+0.480	+0.034	.001	.001	3	7
BRCA	APBB2 →	+0.307	+0.038	<.001	<.001	3	7
OV	MYBBP1A_S1163 →	-0.655	-0.040	.001	.003	3	7
LSCC	TNS2_S102 →	+0.685	+0.042	.002	.007	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071071 vs VIM_S22 — OV

Explore this scatter interactively →