Regulation of phospholipid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Regulation of phospholipid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCNS3, GSTM3, and PARD3B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KCNS3 grouped by Regulation of phospholipid biosynthetic process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KCNS3 →	+1.417	+1.122	.003	<.001	3	4
KIDNEY	GSTM3 →	-2.957	-1.311	.001	<.001	3	4
LIVER	PARD3B →	-1.041	-1.546	.004	.003	3	3
SKIN	MACROD1 →	+1.018	+0.977	.006	.001	3	3
CNS	RAB27B →	-1.685	-0.868	<.001	.003	3	3
LARGE_INTESTINE	TTC9C →	+0.331	+0.827	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KCNS3 by Regulation of phospholipid biosynthetic process activity — LARGE_INTESTINE

Explore this box plot interactively →