Regulation of phospholipid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Regulation of phospholipid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LGALS1, SPSB1, and CAPN2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of phospholipid biosynthetic process activity versus LGALS1 in BLOOD_Lymphoma (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	LGALS1 →	+3.359	+0.180	.009	.002	3	8
BONE	SPSB1 →	+1.630	+0.449	.008	.002	3	8
BLOOD_Lymphoma	CAPN2 →	+3.276	+0.193	.002	<.001	3	7
BONE	PDLIM7 →	+1.703	+0.413	.001	.001	3	7
BONE	HIF1A →	+1.523	+0.413	.003	.001	3	7
BONE	LTBP2 →	+2.835	+0.414	.002	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071071 vs LGALS1 — BLOOD_Lymphoma

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