Poly(A)-dependent snoRNA 3'-end processing

Across TCGA cell cohorts, RNA activity of the Poly(A)-dependent snoRNA 3'-end processing pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC37A1, TAMM41, and CHCHD4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Poly(A)-dependent snoRNA 3'-end processing activity versus SLC37A1 in URINARY_TRACT (Pearson r = -0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	SLC37A1 →	-2.005	-1.211	.003	.008	3	6
KIDNEY	TAMM41 →	+1.492	+2.203	<.001	<.001	3	4
LUNG_SCLC	CHCHD4 →	+0.895	+1.365	.001	<.001	3	4
LUNG_NSCLC_LUAD	TCOF1 →	+0.625	+0.877	.004	.007	2	5
KIDNEY	PMS1 →	+0.657	+1.627	.007	.002	3	4
BREAST	CCDC88A →	+2.508	+1.191	.002	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071051 vs SLC37A1 — URINARY_TRACT

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