Nuclear mRNA surveillance

Across TCGA patient cohorts, RNA activity of the Nuclear mRNA surveillance pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LUC7L3, XPO5, and TRRAP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nuclear mRNA surveillance activity versus LUC7L3 in UCEC (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LUC7L3 →	+0.179	+0.136	<.001	<.001	3	6
HNSC	XPO5 →	+0.385	+0.088	.001	.002	3	6
PDAC	TRRAP →	+0.178	+0.034	.003	<.001	3	6
LSCC	CMTR1 →	+0.314	+0.059	.004	<.001	3	6
LSCC	SFPQ →	+0.137	+0.051	.001	<.001	3	5
LSCC	SMC1A →	+0.235	+0.050	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071028 vs LUC7L3 — UCEC

Explore this scatter interactively →