Nuclear RNA surveillance

Across TCGA patient cohorts, RNA activity of the Nuclear RNA surveillance pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNORA65, POC1A, and VSIR, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nuclear RNA surveillance activity versus SNORA65 in OV (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SNORA65 →	+0.816	+0.182	.001	.002	3	5
GBM	POC1A →	+0.799	+0.249	<.001	<.001	3	4
GBM	VSIR →	-0.738	-0.154	.005	.005	3	4
GBM	CENPH →	+0.990	+0.248	<.001	<.001	3	4
GBM	CHST15 →	-0.495	-0.180	<.001	<.001	3	4
GBM	CP →	-1.447	-0.214	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071027 vs SNORA65 — OV

Explore this scatter interactively →