Nuclear RNA surveillance

Across TCGA pan-cancer cohorts, RNA activity of the Nuclear RNA surveillance pathway is associated with patient survival in 28 of 34 cancer lineages. Pathway activity is summarized from the expression of its 14 member genes.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher Nuclear RNA surveillance pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as BRCA and UCS, show the opposite pattern, with higher activity associated with better survival.

KIRC, ACC, and BRCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.489	0.701	<.001	167	view →
ACC	OS	Median	All	0.651	0.886	<.001	99	view →
BRCA	OS	Tertile	All	0.982	0.940	<.001	86	view →
UCS	DFS	Quartile	III,IV	0.545	0.213	.010	52	view →
UVM	DFS	Median	III,IV	0.211	0.825	<.001	47	view →
SKCM	OS	Quartile	All	0.834	0.714	<.001	41	view →
SCLC	DFS	Median	All	0.783	0.346	.012	32	view →
CHOL	DFS	Tertile	All	0.859	0.179	.003	29	view →
KIRP	DFS	Median	All	0.370	0.702	.008	24	view →
CESC	DFS	Quartile	All	0.827	0.670	.016	18	view →
MESO	OS	Tertile	III,IV	0.208	0.696	.010	18	view →
LGG	OS	Quartile	All	0.249	0.547	.004	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

GO:0071027–KIRC (OS)

Open the KIRC breakdown →