Nuclear RNA surveillance

Across TCGA cell cohorts, RNA activity of the Nuclear RNA surveillance pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HYLS1, PCYOX1L, and PRAME, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HYLS1 grouped by Nuclear RNA surveillance-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	HYLS1 →	-1.433	-0.190	<.001	.001	3	5
OESOPHAGUS	PCYOX1L →	+1.666	+0.207	.005	.008	2	5
OESOPHAGUS	PRAME →	+2.790	+0.253	<.001	<.001	3	4
OESOPHAGUS	LTB4R →	+1.668	+0.270	.002	<.001	3	4
STOMACH	ADM2 →	+1.809	+0.229	<.001	.001	3	4
BONE	SELENOP →	-3.783	-0.283	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HYLS1 by Nuclear RNA surveillance activity — URINARY_TRACT

Explore this box plot interactively →