Nuclear RNA surveillance

Across TCGA cell cohorts, RNA activity of the Nuclear RNA surveillance pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EXOSC2, NOC2L, and FAM216A, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nuclear RNA surveillance activity versus EXOSC2 in SKIN (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	EXOSC2 →	+0.685	+1.621	.002	.001	3	9
KIDNEY	NOC2L →	+1.250	+1.759	.008	.002	3	8
BREAST	FAM216A →	+1.037	+1.261	.002	.001	3	8
CNS	NOP56 →	+0.719	+1.353	.005	.001	3	7
BONE	MRPS25 →	+1.141	+1.799	.001	.002	3	7
BONE	DHX30 →	+0.812	+2.214	.002	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071027 vs EXOSC2 — SKIN

Explore this scatter interactively →