Demethylation

Across TCGA cell cohorts, RNA activity of the Demethylation pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POR, RPL35A, and PLBD2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Demethylation activity versus POR in CNS (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	POR →	+1.576	+0.931	.001	.007	1	7
LARGE_INTESTINE	RPL35A →	-0.756	-0.282	.004	.007	3	4
BLOOD_Leukemia	PLBD2 →	+1.501	+1.026	<.001	.003	3	4
BLOOD_Leukemia	BAMBI →	+1.701	+1.072	<.001	.002	2	4
BLOOD_Lymphoma	UCK1 →	-0.501	-1.123	.005	.003	3	3
BLOOD_Lymphoma	MSI2 →	-1.224	-0.983	.004	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070988 vs POR — CNS

Explore this scatter interactively →