Left/right axis specification

Across TCGA patient cohorts, RNA activity of the Left/right axis specification pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WDR19, CLPP, and DYNC2H1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Left/right axis specification activity versus WDR19 in OV (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	WDR19 →	+0.369	+0.059	.002	.008	2	7
COAD	CLPP →	-0.326	-0.035	<.001	.004	3	6
OV	DYNC2H1 →	+0.385	+0.074	.002	.001	2	7
LUAD	HDGFL3 →	+0.480	+0.070	<.001	<.001	3	6
PDAC	IFT140 →	+0.234	+0.054	<.001	<.001	3	6
BRCA	NFIA →	+0.346	+0.034	.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070986 vs WDR19 — OV

Explore this scatter interactively →