Left/right axis specification

Across TCGA patient cohorts, RNA activity of the Left/right axis specification pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MLEC, HIF1A-AS1, and CEP43, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Left/right axis specification activity versus MLEC in CCRCC (Pearson r = -0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	MLEC →	+0.426	+0.301	.004	.002	3	3
GBM	HIF1A-AS1 →	+0.414	+0.222	.003	.002	3	3
LUAD	CEP43 →	+0.235	+0.456	.004	.001	3	3
BRCA	NETO1 →	-0.371	-0.439	.005	.005	3	3
LUAD	ATP2C2-AS1 →	+0.339	+0.419	.002	.001	3	3
OV	DEPDC7 →	-0.728	-0.401	.003	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070986 vs MLEC — CCRCC

Explore this scatter interactively →