Left/right axis specification

Across TCGA patient cohorts, RNA activity of the Left/right axis specification pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IRS1_S413, CITED2, and PDS5B_S1358, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Left/right axis specification activity versus IRS1_S413 in COAD (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	IRS1_S413 →	+0.845	+0.393	.002	.004	3	3
HNSC	CITED2 →	+0.849	+0.420	<.001	<.001	3	3
OV	PDS5B_S1358 →	-0.720	-0.450	<.001	<.001	3	3
HNSC	PRR15_S49 →	-0.944	-0.400	<.001	<.001	3	3
BRCA	GPKOW_T216 →	+0.588	+0.725	<.001	<.001	3	3
BRCA	PDZD2_S514 →	+0.522	+0.361	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070986 vs IRS1_S413 — COAD

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