Bone maturation

Across TCGA patient cohorts, RNA activity of the Bone maturation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEPTIN8, TNS2_S120, and ILK, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Bone maturation activity versus SEPTIN8 in LSCC (Pearson r = 0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SEPTIN8 →	+0.294	+0.070	<.001	<.001	3	8
LSCC	TNS2_S120 →	+0.515	+0.052	<.001	<.001	3	8
OV	ILK →	+0.532	+0.079	<.001	<.001	3	8
UCEC	VCL_S795 →	+0.601	+0.069	<.001	<.001	3	8
OV	TNS2 →	+0.427	+0.042	<.001	.001	3	7
LSCC	TNS2_S102 →	+0.684	+0.048	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070977 vs SEPTIN8 — LSCC

Explore this scatter interactively →