Bone maturation

Across TCGA patient cohorts, RNA activity of the Bone maturation pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LMOD1, IRAG1, and GLT8D2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Bone maturation activity versus LMOD1 in OV (Pearson r = 0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	LMOD1 →	+1.046	+0.476	<.001	<.001	3	8
OV	IRAG1 →	+1.073	+0.569	<.001	<.001	3	8
BRCA	GLT8D2 →	+0.987	+0.898	<.001	<.001	3	7
OV	PDLIM3 →	+1.213	+0.516	.001	<.001	3	7
OV	GREM1 →	+1.106	+0.422	.001	.002	3	7
OV	CALHM5 →	+0.857	+0.623	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070977 vs LMOD1 — OV

Explore this scatter interactively →