Bone maturation

Across TCGA cell cohorts, RNA activity of the Bone maturation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FRAT2, CELF3, and STIM1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FRAT2 grouped by Bone maturation-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FRAT2 →	-1.148	-1.129	<.001	<.001	3	4
OVARY	CELF3 →	-0.049	-1.167	.005	.001	2	5
UPPER_AERODIGESTIVE_TRACT	STIM1 →	+1.439	+1.520	<.001	.001	3	4
OVARY	PRR16 →	+1.350	+1.002	.003	.001	3	4
BONE	PPP2R3A →	+1.655	+0.809	<.001	.004	3	4
BONE	STRN →	+1.137	+1.308	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FRAT2 by Bone maturation activity — LARGE_INTESTINE

Explore this box plot interactively →