Neutrophil-mediated killing of gram-negative bacterium

Across TCGA patient cohorts, RNA activity of the Neutrophil-mediated killing of gram-negative bacterium pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLC16A3_S436, TREM1, and MYSM1_S340, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neutrophil-mediated killing of gram-negative bacterium activity versus SLC16A3_S436 in PDAC (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SLC16A3_S436 →	+0.946	+0.107	<.001	<.001	2	7
GBM	TREM1 →	+1.511	+0.186	<.001	<.001	3	6
PDAC	MYSM1_S340 →	-0.611	-0.101	<.001	<.001	3	6
GBM	PHC1_S664 →	-0.443	-0.111	.004	<.001	3	6
GBM	PLAU →	+0.838	+0.175	<.001	<.001	3	6
GBM	PLAUR →	+0.817	+0.152	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070945 vs SLC16A3_S436 — PDAC

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