Neutrophil-mediated killing of gram-negative bacterium

Across TCGA pan-cancer cohorts, RNA activity of the Neutrophil-mediated killing of gram-negative bacterium pathway is associated with patient survival in 25 of 34 cancer lineages. Pathway activity is summarized from the expression of its 6 member genes.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher Neutrophil-mediated killing of gram-negative bacterium pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRC and UVM, show the opposite pattern, with higher activity associated with better survival.

HNSC, BRCA, and KIRC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.266	0.427	<.001	95	view →
BRCA	OS	Quartile	All	0.473	0.645	<.001	72	view →
KIRC	OS	Median	II,III,IV	0.648	0.414	<.001	67	view →
UVM	OS	Quartile	All	0.946	0.491	.006	45	view →
LIHC	OS	Tertile	All	0.742	0.439	<.001	24	view →
THCA	DFS	Quartile	All	0.640	0.941	.002	19	view →
SCLC	OS	Median	II,III,IV	0.421	1.000	.002	19	view →
UCS	DFS	Median	II,III,IV	0.172	0.463	.040	18	view →
CHOL	DFS	Quartile	II,III,IV	0.089	0.642	.015	16	view →
DLBC	OS	Median	II,III,IV	0.402	0.937	.030	14	view →
SARC	OS	Tertile	All	0.760	0.932	<.001	13	view →
LGG	DFS	Quartile	All	0.558	0.360	.018	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GO:0070945–HNSC (DFS)

Open the HNSC breakdown →