Neutrophil-mediated killing of gram-negative bacterium

Across TCGA patient cohorts, RNA activity of the Neutrophil-mediated killing of gram-negative bacterium pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are S100A8, S100A9, and SLC11A1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neutrophil-mediated killing of gram-negative bacterium activity versus S100A8 in CCRCC (Pearson r = 0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	S100A8 →	+0.721	+0.127	<.001	<.001	3	5
CCRCC	S100A9 →	+0.856	+0.138	<.001	<.001	3	4
CCRCC	SLC11A1 →	+0.620	+0.105	.001	.007	3	4
LUAD	SOCS3 →	+0.823	+0.092	<.001	.003	2	5
BRCA	LYPLAL1 →	-0.444	-0.173	<.001	<.001	3	3
BRCA	POLR3K →	-0.432	-0.141	.009	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070945 vs S100A8 — CCRCC

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