Neutrophil-mediated killing of gram-negative bacterium

Across TCGA cell cohorts, RNA activity of the Neutrophil-mediated killing of gram-negative bacterium pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CPT1A, H2AJ, and PYCR3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CPT1A grouped by Neutrophil-mediated killing of gram-negative bacterium-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CPT1A →	+1.738	+0.960	.002	.001	3	4
BREAST	H2AJ →	+1.850	+1.050	<.001	.001	3	4
BLOOD_Leukemia	PYCR3 →	+0.752	+0.692	.006	.007	3	3
BLOOD_Lymphoma	TRPC1 →	-1.680	-2.079	.008	.004	2	4
BLOOD_Lymphoma	NMB →	+1.940	+2.119	<.001	.003	2	4
STOMACH	CLMN →	+2.134	+1.250	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CPT1A by Neutrophil-mediated killing of gram-negative bacterium activity — LUNG_SCLC

Explore this box plot interactively →