Neutrophil-mediated killing of gram-negative bacterium

Across TCGA cell cohorts, RNA activity of the Neutrophil-mediated killing of gram-negative bacterium pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TREM1, BHLHB9, and ZNF331, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neutrophil-mediated killing of gram-negative bacterium activity versus TREM1 in BLOOD_Lymphoma (Pearson r = 0.90).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	TREM1 →	+1.648	+0.772	<.001	<.001	3	12
OESOPHAGUS	BHLHB9 →	-0.833	-0.139	<.001	<.001	3	7
KIDNEY	ZNF331 →	-1.392	-0.200	<.001	.001	3	6
BLOOD_Leukemia	ZNF738 →	-1.427	-1.089	<.001	<.001	3	6
BLOOD_Leukemia	PRPSAP2 →	-0.566	-0.805	<.001	<.001	3	6
CNS	RBMX →	-0.427	-0.120	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070945 vs TREM1 — BLOOD_Lymphoma

Explore this scatter interactively →