Neutrophil mediated cytotoxicity

Across TCGA patient cohorts, RNA activity of the Neutrophil mediated cytotoxicity pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RETN, S100A12, and S100A8, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neutrophil mediated cytotoxicity activity versus RETN in LSCC (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RETN →	+1.195	+0.090	<.001	<.001	3	6
LSCC	S100A12 →	+1.598	+0.098	<.001	<.001	3	6
LSCC	S100A8 →	+1.598	+0.098	<.001	<.001	3	6
LSCC	S100A9 →	+1.577	+0.094	<.001	<.001	3	6
BRCA	UBA2 →	-0.307	-0.060	<.001	.001	3	6
LSCC	SIN3B_S1003 →	-0.942	-0.084	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070942 vs RETN — LSCC

Explore this scatter interactively →