Neutrophil mediated cytotoxicity

Across TCGA cell cohorts, RNA activity of the Neutrophil mediated cytotoxicity pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNASE1L3, VEGFA, and SCNN1B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DNASE1L3 grouped by Neutrophil mediated cytotoxicity-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	DNASE1L3 →	-0.152	-0.902	<.001	.001	3	5
LUNG_NSCLC_LUAD	VEGFA →	-0.159	-0.655	.001	.004	3	4
LUNG_NSCLC_LUAD	SCNN1B →	-0.101	-0.418	.007	.004	3	4
BLOOD_Lymphoma	TREM1 →	-0.572	-2.072	.003	<.001	3	4
BREAST	KAT5 →	+0.194	+0.329	.001	.001	3	4
SOFT_TISSUE	ZNRD2 →	+0.355	+1.287	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DNASE1L3 by Neutrophil mediated cytotoxicity activity — SKIN

Explore this box plot interactively →