Neutrophil mediated cytotoxicity

Across TCGA cell cohorts, RNA activity of the Neutrophil mediated cytotoxicity pathway is significantly associated with the protein abundance of multiple proteins, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RNASET2, BLVRB, and MPO, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neutrophil mediated cytotoxicity activity versus RNASET2 in BLOOD_Leukemia (Pearson r = 0.60).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RNASET2 →	+3.157	+1.828	<.001	<.001	3	3
BLOOD_Lymphoma	BLVRB →	-1.873	-2.531	<.001	<.001	3	3
LUNG_SCLC	MPO →	+3.793	+2.036	<.001	<.001	3	3
LARGE_INTESTINE	PTP4A1 →	-1.311	-1.872	.004	<.001	3	3
BLOOD_Leukemia	CTSG →	+4.660	+0.834	<.001	<.001	3	3
BLOOD_Leukemia	BCL7A →	-0.575	-1.196	.009	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070942 vs RNASET2 — BLOOD_Leukemia

Explore this scatter interactively →