3'-UTR-mediated mRNA stabilization

Across TCGA patient cohorts, RNA activity of the 3'-UTR-mediated mRNA stabilization pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDT1, SNPH, and VRK1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, 3'-UTR-mediated mRNA stabilization activity versus CDT1 in BRCA (Pearson r = 0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CDT1 →	+1.003	+0.145	<.001	.001	3	5
BRCA	SNPH →	-0.976	-0.163	<.001	.001	3	4
HNSC	VRK1 →	+0.588	+0.114	.003	.008	3	4
HNSC	CCDC77 →	+0.714	+0.206	.004	<.001	3	4
BRCA	MCM7 →	+0.603	+0.142	<.001	.001	3	4
LSCC	SYPL1P2 →	+0.486	+0.146	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070935 vs CDT1 — BRCA

Explore this scatter interactively →