CRD-mediated mRNA stabilization

Across TCGA patient cohorts, RNA activity of the CRD-mediated mRNA stabilization pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL7, POGZ, and RPF2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, CRD-mediated mRNA stabilization activity versus RPL7 in GBM (Pearson r = -0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RPL7 →	-0.434	-0.073	<.001	<.001	3	6
GBM	POGZ →	+0.288	+0.058	.003	.004	3	6
GBM	RPF2 →	-0.375	-0.067	<.001	<.001	3	6
BRCA	RPL6 →	-0.517	-0.051	<.001	<.001	3	6
GBM	RSF1 →	+0.314	+0.061	.005	.002	3	5
BRCA	IGF2BP3 →	-1.783	-0.070	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070934 vs RPL7 — GBM

Explore this scatter interactively →