CRD-mediated mRNA stabilization

Across TCGA pan-cancer cohorts, RNA activity of the CRD-mediated mRNA stabilization pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 11 member genes.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher CRD-mediated mRNA stabilization pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UCS and LGG, show the opposite pattern, with higher activity associated with better survival.

UCS, LGG, and SKCM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Tertile	III,IV	0.582	0.230	.003	70	view →
LGG	DFS	Median	All	0.515	0.286	<.001	50	view →
SKCM	OS	Tertile	II,III,IV	0.945	0.757	.003	47	view →
BLCA	OS	Tertile	III,IV	0.517	0.237	.007	41	view →
BRCA	OS	Tertile	III,IV	0.951	0.834	.004	30	view →
KIRC	DFS	Median	III,IV	0.556	0.390	.010	29	view →
ESCA	DFS	Median	III,IV	0.422	0.231	.019	28	view →
LUSC	DFS	Median	All	0.586	0.692	.015	24	view →
SCLC	OS	Quartile	III,IV	0.721	0.225	.013	18	view →
UCEC	DFS	Tertile	All	0.567	0.684	.009	16	view →
LIHC	DFS	Quartile	III,IV	0.744	0.209	<.001	15	view →
ACC	DFS	Median	IV	0.472	0.089	.012	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0070934–UCS (DFS)

Open the UCS breakdown →