CRD-mediated mRNA stabilization

Across TCGA patient cohorts, RNA activity of the CRD-mediated mRNA stabilization pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IGF2BP3, SNORD65C, and IGF2BP2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, CRD-mediated mRNA stabilization activity versus IGF2BP3 in HNSC (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	IGF2BP3 →	+1.710	+0.371	<.001	<.001	3	9
HNSC	SNORD65C →	+2.211	+0.327	<.001	<.001	3	8
GBM	IGF2BP2 →	+1.391	+0.183	<.001	.001	3	8
LUAD	CDCA3 →	+0.767	+0.239	.002	.002	3	7
HNSC	HELLS →	+0.615	+0.241	<.001	<.001	3	7
UCEC	IGF2BP2-AS1 →	+1.239	+0.170	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070934 vs IGF2BP3 — HNSC

Explore this scatter interactively →