CRD-mediated mRNA stabilization

Across TCGA cell cohorts, RNA activity of the CRD-mediated mRNA stabilization pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DHX37, KHSRP, and CCDC86, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, CRD-mediated mRNA stabilization activity versus DHX37 in PANCREAS (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	DHX37 →	+0.988	+0.227	.006	<.001	3	8
LIVER	KHSRP →	+1.474	+0.590	<.001	<.001	3	8
BONE	CCDC86 →	+1.034	+0.266	<.001	.001	3	7
BONE	DNMT1 →	+1.254	+0.265	.002	.004	3	7
OVARY	STIP1 →	+0.829	+0.229	<.001	<.001	3	7
LIVER	VARS1 →	+1.149	+0.465	.008	.003	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070934 vs DHX37 — PANCREAS

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