RISC complex assembly

Across TCGA cell cohorts, RNA activity of the RISC complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPG11, LFNG, and MAN2B1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SPG11 grouped by RISC complex assembly-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SPG11 →	-0.767	-0.319	.001	<.001	3	5
LUNG_NSCLC_LUAD	LFNG →	+1.516	+0.188	.005	.001	3	4
CNS	MAN2B1 →	+0.666	+0.311	.002	.006	3	4
PANCREAS	SIRT7 →	-0.787	-0.306	.003	.001	3	4
PANCREAS	ZBTB12 →	+0.649	+0.189	.003	.008	3	4
OVARY	SLC41A2 →	+1.125	+0.254	.005	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SPG11 by RISC complex assembly activity — SOFT_TISSUE

Explore this box plot interactively →