Regulation of regulatory ncRNA processing

Across TCGA cell cohorts, RNA activity of the Regulation of regulatory ncRNA processing pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MIPEP, ZNF773, and PUSL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MIPEP grouped by Regulation of regulatory ncRNA processing-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	MIPEP →	-0.844	-1.201	.001	.002	3	4
SOFT_TISSUE	ZNF773 →	+0.547	+1.044	.008	.004	3	4
LIVER	PUSL1 →	-0.777	-1.096	.003	.004	3	4
BREAST	TMEM254 →	-0.899	-0.877	.006	<.001	3	4
BREAST	P2RX5 →	+1.401	+0.834	<.001	<.001	3	4
STOMACH	LMTK3 →	-1.331	-0.834	.003	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MIPEP by Regulation of regulatory ncRNA processing activity — PANCREAS

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