Regulatory ncRNA processing

Across TCGA patient cohorts, RNA activity of the Regulatory ncRNA processing pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSDC2, MELK, and KIF14, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulatory ncRNA processing activity versus CSDC2 in GBM (Pearson r = -0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CSDC2 →	-0.916	-0.159	<.001	.001	3	6
PDAC	MELK →	+0.674	+0.160	<.001	.001	3	6
LSCC	KIF14 →	+0.593	+0.145	.001	.006	3	6
LSCC	CDCA8 →	+0.542	+0.142	.002	.005	3	6
BRCA	ZCCHC24 →	-0.668	-0.184	<.001	<.001	3	6
BRCA	PODN →	-1.147	-0.205	.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070918 vs CSDC2 — GBM

Explore this scatter interactively →