Transcription preinitiation complex assembly

Across TCGA patient cohorts, RNA activity of the Transcription preinitiation complex assembly pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC1A, SMC3, and IK, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transcription preinitiation complex assembly activity versus SMC1A in LSCC (Pearson r = 0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SMC1A →	+0.331	+0.049	<.001	<.001	3	7
HNSC	SMC3 →	+0.253	+0.063	.001	.002	3	7
LSCC	IK →	+0.153	+0.031	<.001	<.001	3	7
LSCC	RAD21 →	+0.285	+0.042	<.001	.001	3	7
LUAD	SRRT →	+0.208	+0.036	<.001	<.001	3	7
LSCC	GTF3C4 →	+0.428	+0.048	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070897 vs SMC1A — LSCC

Explore this scatter interactively →