Negative regulation of glycogen metabolic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of glycogen metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HSPB3, KCNRG, and LAMA5-AS1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of glycogen metabolic process activity versus HSPB3 in COAD (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	HSPB3 →	+0.892	+0.241	.001	.008	3	2
COAD	KCNRG →	-0.228	-0.192	.002	.003	3	2
COAD	LAMA5-AS1 →	-0.125	-0.207	.002	.004	3	2
COAD	BDH2P1 →	+0.406	+0.162	<.001	.004	3	2
CCRCC	RPS12P20 →	-0.438	-0.577	.008	.001	3	2
OV	SLC6A13 →	-1.025	-0.232	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070874 vs HSPB3 — COAD

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