Negative regulation of glycogen metabolic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of glycogen metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GSK3B, ATG3, and RPS12, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of glycogen metabolic process activity versus GSK3B in OESOPHAGUS (Pearson r = 0.69).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	GSK3B →	+1.063	+0.425	<.001	.008	1	11
URINARY_TRACT	ATG3 →	+1.027	+0.361	.005	.009	3	6
KIDNEY	RPS12 →	+0.944	+0.468	.004	.001	3	6
BLOOD_Leukemia	YWHAQ →	+0.450	+0.367	.002	.007	2	6
KIDNEY	TAP1 →	-1.306	-0.464	<.001	<.001	3	5
KIDNEY	CNBP →	+1.319	+0.536	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070874 vs GSK3B — OESOPHAGUS

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