Negative regulation of protein exit from endoplasmic reticulum

Across TCGA patient cohorts, RNA activity of the Negative regulation of protein exit from endoplasmic reticulum pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HLA-DOB, FIS1, and P2RX1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein exit from endoplasmic reticulum activity versus HLA-DOB in HNSC (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	HLA-DOB →	+0.644	+0.140	.004	.002	2	5
UCEC	FIS1 →	-0.805	-0.131	.006	.003	3	4
LSCC	P2RX1 →	+0.545	+0.163	<.001	<.001	3	4
LSCC	DERL3 →	+0.614	+0.157	.003	.002	3	4
GBM	RN7SKP22 →	+0.356	+0.157	.002	.004	2	5
BRCA	RALGDS →	+0.265	+0.193	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070862 vs HLA-DOB — HNSC

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