Regulation of protein exit from endoplasmic reticulum

Across TCGA patient cohorts, RNA activity of the Regulation of protein exit from endoplasmic reticulum pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GLCCI1, PDK1, and CCDC191, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein exit from endoplasmic reticulum activity versus GLCCI1 in LUAD (Pearson r = 0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	GLCCI1 →	+0.702	+0.135	.002	.004	3	4
UCEC	PDK1 →	+0.884	+0.228	<.001	<.001	3	4
PDAC	CCDC191 →	-0.350	-0.197	<.001	<.001	2	4
OV	HBA2 →	+1.657	+0.365	<.001	<.001	3	3
OV	HBA1 →	+1.327	+0.334	<.001	<.001	3	3
BRCA	OSER1-DT →	-0.509	-0.217	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070861 vs GLCCI1 — LUAD

Explore this scatter interactively →