Q-omics provides the consensus-scored OSER1-DT profile across patient tissues and cancer cell-line models. OSER1-DT expression is associated with patient survival in 26 of 34 cancer types, with the highest sampling consensus in UCEC. Among the 18 cancer types available for tumor–normal comparison, OSER1-DT is differentially expressed in 11, with the highest sampling consensus in KICH. Additionally, OSER1-DT RNA expression shows 19,616 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight UCEC, KICH, and ACC as cancer lineages where OSER1-DT shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for OSER1-DT — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes OSER1-DT survival associations across molecular data types. OSER1-DT RNA expression shows survival associations in the most cancer types (26). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible OSER1-DT RNA expression–survival associations across cancer types. High OSER1-DT expression shows unfavorable associations in UCEC and LIHC, but favorable associations in UCS, LGG, LUAD and KIRC. The UCEC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .003). Together, the overview and detailed table identify UCEC as the clearest survival context for OSER1-DT RNA expression.
This table summarizes OSER1-DT tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11. The strongest signals are observed in LIHC for RNA.
This table ranks reproducible tumor–normal expression differences for OSER1-DT. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. OSER1-DT shows lower tumor expression in KICH, UCEC, THCA and BRCA and higher tumor expression in LIHC and CHOL. The KICH box plot shows higher OSER1-DT RNA expression in normal versus tumor tissue (log2 FC = −1.213, t-test p < 0.001).
This table shows molecular features associated with OSER1-DT in patient tissues and cancer cell lines. In patient samples, OSER1-DT shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set.
