Aggresome assembly

Across TCGA cell cohorts, RNA activity of the Aggresome assembly pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAAP20, TNFRSF11A, and ADGRV1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FAAP20 grouped by Aggresome assembly-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	FAAP20 →	+0.923	+1.271	.005	.004	3	5
OVARY	TNFRSF11A →	-0.642	-0.917	.006	.005	3	4
OVARY	ADGRV1 →	+1.874	+1.243	<.001	<.001	3	4
OVARY	ANGPTL4 →	-2.015	-0.737	.001	.002	3	4
OESOPHAGUS	INAFM1 →	+0.816	+1.099	<.001	.001	3	4
STOMACH	HIKESHI →	+0.544	+1.011	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FAAP20 by Aggresome assembly activity — PANCREAS

Explore this box plot interactively →