Dehydroascorbic acid transport

Across TCGA cell cohorts, RNA activity of the Dehydroascorbic acid transport pathway is significantly associated with the shRNA dependency of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COPA, DSEL, and ADIPOQ, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, COPA grouped by Dehydroascorbic acid transport-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	COPA →	+0.360	+0.206	.004	.003	3	6
OVARY	DSEL →	-0.163	-0.104	.005	.007	3	4
LARGE_INTESTINE	ADIPOQ →	+0.193	+0.174	.003	.008	3	4
BREAST	TBC1D3 →	+0.196	+0.368	.001	.003	3	4
LUNG_NSCLC_LUSC	BCORL1 →	+0.235	+0.295	.001	.004	3	4
BLOOD_Leukemia	CACNG7 →	-0.272	-0.199	.006	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

COPA by Dehydroascorbic acid transport activity — OESOPHAGUS

Explore this box plot interactively →