Response to interleukin-15

Across TCGA patient cohorts, RNA activity of the Response to interleukin-15 pathway is significantly associated with the RNA expression of multiple genes, with the SARC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CMKLR1, IL2RB, and LILRB1, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to interleukin-15 activity versus CMKLR1 in SARC (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SARC	CMKLR1 →	+1.639	+0.069	<.001	<.001	3	34
CHOL	IL2RB →	+2.590	+0.134	<.001	<.001	3	33
SKCM	LILRB1 →	+1.704	+0.097	<.001	<.001	3	33
SCLC	JAK3 →	+1.737	+0.219	<.001	<.001	3	33
SCLC	ABI3 →	+2.763	+0.231	<.001	<.001	3	33
SCLC	CD80 →	+1.127	+0.232	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070672 vs CMKLR1 — SARC

Explore this scatter interactively →