Response to interleukin-15

Across TCGA patient cohorts, RNA activity of the Response to interleukin-15 pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SAMSN1_S107, SKAP2, and THEMIS2_T593, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to interleukin-15 activity versus SAMSN1_S107 in UCEC (Pearson r = 0.60).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SAMSN1_S107 →	+1.076	+0.139	<.001	<.001	3	10
OV	SKAP2 →	+0.684	+0.072	<.001	<.001	3	10
OV	THEMIS2_T593 →	+1.113	+0.080	.005	.004	3	10
UCEC	WAS →	+0.535	+0.074	<.001	<.001	3	10
UCEC	WIPF1 →	+0.386	+0.070	<.001	<.001	3	10
LSCC	CD4 →	+0.622	+0.099	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070672 vs SAMSN1_S107 — UCEC

Explore this scatter interactively →