Response to interleukin-15

Across TCGA patient cohorts, RNA activity of the Response to interleukin-15 pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RIN3, LYL1, and ELMO1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to interleukin-15 activity versus RIN3 in BRCA (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RIN3 →	+0.497	+0.495	.007	.002	3	5
HNSC	LYL1 →	+0.707	+0.160	.001	<.001	3	5
LSCC	ELMO1 →	+0.446	+0.360	.002	.003	3	5
HNSC	CSF2RA →	+0.914	+0.202	<.001	<.001	3	5
LSCC	P2RX1 →	+0.781	+0.426	<.001	.001	3	5
LSCC	SCIMP →	+0.511	+0.395	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070672 vs RIN3 — BRCA

Explore this scatter interactively →